Mays, S. and Taylor, G. M. (2002). Osteological and biomolecular study of two possible cases of hypertrophic osteoarthropathy from mediaeval England. J Archaeol Sci 29 (11). Vol 29(11), pp. 1267-1276.

Title
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Title:		 Osteological and biomolecular study of two possible cases of hypertrophic osteoarthropathy from mediaeval England
Issue
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Issue:		 J Archaeol Sci 29 (11)
Series
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Series:		 Journal of Archaeological Science
Volume
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Volume:		 29 (11)
Page Start/End
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Page Start/End:		 1267 - 1276
Biblio Note
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Biblio Note		 Please note that this is a bibliographic record only, as originally entered into the BIAB database. The ADS have no files for download, and unfortunately cannot advise further on where to access hard copy or digital versions.
Publication Type
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Publication Type:		 Journal
Abstract
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Abstract:		 Studies two skeletons from medieval Wharram Percy, North Yorkshire, which show osteological lesions consistent with hypertrophic osteoarthropathy. The primary cause of hypertrophic osteoarthropathy is generally chronic pulmonary disease, usually either cancer or infection; in the pre-antibiotic era it was predominantly the latter. Biomolecular analyses indicate the presence of Mycobacterium tuberculosis DNA in one of the specimens, strongly indicating that pulmonary tuberculosis was the eliciting factor in this case. This is the first time that a primary cause for hypertrophic osteoarthropathy has been firmly identified in an ancient skeleton and illustrates the potential of a dual approach using both osteological and biomolecular techniques for enhancing our understanding of early disease. The other specimen proved negative for M. tuberculosis complex DNA, however the presence of infectious rib lesions allowed us to suggest that some non-tuberculous pulmonary infection was likely the primary cause of hypertrophic osteoarthropathy in this case.
Author
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Author:		 Simon Mays
G M Taylor
Year of Publication
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Year of Publication:		 2002
Locations
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Subjects / Periods:
Ancient Skeleton (Auto Detected Subject)
MEDIEVAL (Historic England Periods)
Mycobacterium Tuberculosis (Auto Detected Subject)
Source
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Source:
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BIAB (The British & Irish Archaeological Bibliography (BIAB))
Created Date
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Created Date:		 14 Jan 2003